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| Acceso al texto completo restringido a Biblioteca INIA Las Brujas. Por información adicional contacte bibliolb@inia.org.uy. |
Registro completo
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Biblioteca (s) : |
INIA Las Brujas. |
Fecha : |
30/06/2023 |
Actualizado : |
30/06/2023 |
Tipo de producción científica : |
Artículos en Revistas Indexadas Internacionales |
Autor : |
GIANNITTI, F.; GARCÍA, J. P.; ADAMS, V.; ARMENDANO, J.; BEINGESSER, J.; ROOD, J.; UZAL, F. A. |
Afiliación : |
FEDERICO GIANNITTI, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; JORGE P. GARCÍA, Universidad Nacional del Centro de la Provincia de Buenos Aires, Tandil, Buenos Aires, Argentina; VICKI ADAMS, Monash University, Parkville, Victoria, Australia; JOAQUÍN I. ARMENDANO, Universidad Nacional del Centro de la Provincia de Buenos Aires, Tandil, Buenos Aires, Argentina; JULIANN BEINGESSER, California Animal Health and Food Safety Laboratoy, University of California at Davis, San Bernardino, CA; JULIAN I. ROOD, Monash University, Parkville, Victoria, Australia; FRANCISCO A. UZAL, Monash University, Parkville, Victoria, Australia. |
Título : |
Experimental acute Clostridium perfringens type D enterotoxemia in sheep is not characterized by specific renal lesions. |
Complemento del título : |
Infectious Disease - Original Article. |
Fecha de publicación : |
2023 |
Fuente / Imprenta : |
Veterinary Pathology. 2023, vol.60(4):412-419. https://doi.org/10.1177/03009858231171669 |
ISSN : |
0300-9858 (print); 1544-2217 (online). |
DOI : |
10.1177/03009858231171669 |
Idioma : |
Inglés |
Notas : |
Article history: First published online May 12, 2023. -- Corresponding Author: Francisco A. Uzal, California Animal Health and Food Safety Laboratory, School of Veterinary Medicine, University of California at Davis, 105 W CVentral Ave, San Bernardino, CA 92408, USA. Email: fauzal@ucdavis.edu -- Funding: This work was supported by grant R01 AI056177 from the National Institute of Allergy and Infectious Diseases (NIAID). Research at Monash University was also supported by funding provided by the Australian Research Council to the Australian Research Council Centre of Excellence in Structural and Functional Microbial Genomics (grant no. CE0562063). -- |
Contenido : |
ABSTRACT.- Type D enterotoxemia, caused by Clostridium perfringens epsilon toxin (ETX), is one of the most economically important clostridial diseases of sheep. Acute type D enterotoxemia is characterized by well-documented lesions in the nervous, cardiocirculatory, and pulmonary systems. However, discrepancies and confusion exist as to whether renal lesions are part of the spectrum of lesions of this condition, which is controversial considering that for many decades it has been colloquially referred to as "pulpy kidney disease". Here, the authors assess renal changes in an experimental model of acute type D enterotoxemia in sheep and evaluate the possible role of ETX in their genesis. Four groups of 6 sheep each were intraduodenally inoculated with either a wild-type virulent C. perfringens type D strain, an etx knockout mutant unable to produce ETX, the etx mutant strain complemented with the wild-type etx gene that regains the ETX toxin production, or sterile culture medium (control group). All sheep were autopsied less than 24 hours after inoculation; none of them developed gross lesions in the kidneys. Ten predefined histologic renal changes were scored in each sheep. The proportion of sheep with microscopic changes and their severity scores did not differ significantly between groups. Mild intratubular medullary hemorrhage was observed in only 2 of the 12 sheep inoculated with the wild-type or etx-complemented bacterial strains, but not in the 12 sheep of the other 2 groups. The authors conclude that no specific gross or histologic renal lesions are observed in sheep with experimental acute type D enterotoxemia. © The Author(s) 2023 MenosABSTRACT.- Type D enterotoxemia, caused by Clostridium perfringens epsilon toxin (ETX), is one of the most economically important clostridial diseases of sheep. Acute type D enterotoxemia is characterized by well-documented lesions in the nervous, cardiocirculatory, and pulmonary systems. However, discrepancies and confusion exist as to whether renal lesions are part of the spectrum of lesions of this condition, which is controversial considering that for many decades it has been colloquially referred to as "pulpy kidney disease". Here, the authors assess renal changes in an experimental model of acute type D enterotoxemia in sheep and evaluate the possible role of ETX in their genesis. Four groups of 6 sheep each were intraduodenally inoculated with either a wild-type virulent C. perfringens type D strain, an etx knockout mutant unable to produce ETX, the etx mutant strain complemented with the wild-type etx gene that regains the ETX toxin production, or sterile culture medium (control group). All sheep were autopsied less than 24 hours after inoculation; none of them developed gross lesions in the kidneys. Ten predefined histologic renal changes were scored in each sheep. The proportion of sheep with microscopic changes and their severity scores did not differ significantly between groups. Mild intratubular medullary hemorrhage was observed in only 2 of the 12 sheep inoculated with the wild-type or etx-complemented bacterial strains, but not in the 12 sheep of the other 2 ... Presentar Todo |
Palabras claves : |
Clostridium perfringens type D; Enterotoxemia; ETX; Experimental infection; Kidneys; PLATAFORMA DE INVESTIGACIÓN EN SALUD ANIMAL - INIA; Renal pathology; Sheep. |
Asunto categoría : |
L10 Genética y mejoramiento animal |
Marc : |
LEADER 03352naa a2200325 a 4500 001 1064216 005 2023-06-30 008 2023 bl uuuu u00u1 u #d 022 $a0300-9858 (print); 1544-2217 (online). 024 7 $a10.1177/03009858231171669$2DOI 100 1 $aGIANNITTI, F. 245 $aExperimental acute Clostridium perfringens type D enterotoxemia in sheep is not characterized by specific renal lesions.$h[electronic resource] 260 $c2023 500 $aArticle history: First published online May 12, 2023. -- Corresponding Author: Francisco A. Uzal, California Animal Health and Food Safety Laboratory, School of Veterinary Medicine, University of California at Davis, 105 W CVentral Ave, San Bernardino, CA 92408, USA. Email: fauzal@ucdavis.edu -- Funding: This work was supported by grant R01 AI056177 from the National Institute of Allergy and Infectious Diseases (NIAID). Research at Monash University was also supported by funding provided by the Australian Research Council to the Australian Research Council Centre of Excellence in Structural and Functional Microbial Genomics (grant no. CE0562063). -- 520 $aABSTRACT.- Type D enterotoxemia, caused by Clostridium perfringens epsilon toxin (ETX), is one of the most economically important clostridial diseases of sheep. Acute type D enterotoxemia is characterized by well-documented lesions in the nervous, cardiocirculatory, and pulmonary systems. However, discrepancies and confusion exist as to whether renal lesions are part of the spectrum of lesions of this condition, which is controversial considering that for many decades it has been colloquially referred to as "pulpy kidney disease". Here, the authors assess renal changes in an experimental model of acute type D enterotoxemia in sheep and evaluate the possible role of ETX in their genesis. Four groups of 6 sheep each were intraduodenally inoculated with either a wild-type virulent C. perfringens type D strain, an etx knockout mutant unable to produce ETX, the etx mutant strain complemented with the wild-type etx gene that regains the ETX toxin production, or sterile culture medium (control group). All sheep were autopsied less than 24 hours after inoculation; none of them developed gross lesions in the kidneys. Ten predefined histologic renal changes were scored in each sheep. The proportion of sheep with microscopic changes and their severity scores did not differ significantly between groups. Mild intratubular medullary hemorrhage was observed in only 2 of the 12 sheep inoculated with the wild-type or etx-complemented bacterial strains, but not in the 12 sheep of the other 2 groups. The authors conclude that no specific gross or histologic renal lesions are observed in sheep with experimental acute type D enterotoxemia. © The Author(s) 2023 653 $aClostridium perfringens type D 653 $aEnterotoxemia 653 $aETX 653 $aExperimental infection 653 $aKidneys 653 $aPLATAFORMA DE INVESTIGACIÓN EN SALUD ANIMAL - INIA 653 $aRenal pathology 653 $aSheep 700 1 $aGARCÍA, J. P. 700 1 $aADAMS, V. 700 1 $aARMENDANO, J. 700 1 $aBEINGESSER, J. 700 1 $aROOD, J. 700 1 $aUZAL, F. A. 773 $tVeterinary Pathology. 2023, vol.60(4):412-419. https://doi.org/10.1177/03009858231171669
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INIA Las Brujas (LB) |
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Registro completo
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Biblioteca (s) : |
INIA Tacuarembó; INIA Treinta y Tres. |
Fecha actual : |
12/01/2015 |
Actualizado : |
03/02/2018 |
Tipo de producción científica : |
Capítulo en Libro Técnico-Científico |
Autor : |
BRIANO, D.; LOPEZ, J.A.; VIANA, S.; JIMENEZ DE ARECHAGA, C.; VELAZCO, J.; PEREYRA, F.; LOPEZ, C.; QUINTANS, G. |
Afiliación : |
D. BRIANO, Estudiante de grado de Facultad de Agronomía, Uruguay; J.A. LOPEZ, Estudiante de grado Facultad de Agronomía, Uruguay; S. VIANA, Estudiante de grado, Facultad de Agronomía, Uruguay; CAROLINA JIMENEZ DE ARECHAGA BARAIBAR, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; JOSE IGNACIO VELAZCO DE LOS REYES, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; F. PEREYRA, Facultad de Agronomía, Uruguay; C. LOPEZ, Facultad de Agronomía, Uruguay; GRACIELA QUINTANS ILARIA, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay. |
Título : |
Efecto de la aplicación de destete temporario en función de la actividad ovárica durante en entore sobre el porcentaje de preñez en vacas para carne. |
Fecha de publicación : |
2014 |
Fuente / Imprenta : |
In: BERRETTA, E.; MONTOSSI, F.; BRITO, G. (Ed.). Alternativas tecnológicas para los sistemas ganaderos del basalto. Montevideo, UY: INIA, 2014. |
Páginas : |
245-246 |
Serie : |
(Serie Técnica; 217) |
ISSN : |
1688-9266 |
Idioma : |
Español |
Contenido : |
El objetivo del presente estudio fue evaluar la aplicación del destete temporario con tablilla nasal durante 14 días en función de
la actividad ovárica (AO) en la mitad del entore sobre el porcentaje de preñez. |
Palabras claves : |
ACTIVIDAD OVÁRICA; ANESTRO POSPARTO; CONTROL AMAMANTAMIENTO; TABLILLA NASAL. |
Thesagro : |
ANESTRO POSPARTO; DESTETE TEMPORARIO; ENTORE; VACAS DE CRIA. |
Asunto categoría : |
-- L01 Ganadería |
URL : |
http://www.ainfo.inia.uy/digital/bitstream/item/7436/1/ST-217-292-293..pdf
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Marc : |
LEADER 01285naa a2200337 a 4500 001 1052001 005 2018-02-03 008 2014 bl uuuu u00u1 u #d 022 $a1688-9266 100 1 $aBRIANO, D. 245 $aEfecto de la aplicación de destete temporario en función de la actividad ovárica durante en entore sobre el porcentaje de preñez en vacas para carne. 260 $c2014 300 $a245-246 490 $a(Serie Técnica; 217) 520 $aEl objetivo del presente estudio fue evaluar la aplicación del destete temporario con tablilla nasal durante 14 días en función de la actividad ovárica (AO) en la mitad del entore sobre el porcentaje de preñez. 650 $aANESTRO POSPARTO 650 $aDESTETE TEMPORARIO 650 $aENTORE 650 $aVACAS DE CRIA 653 $aACTIVIDAD OVÁRICA 653 $aANESTRO POSPARTO 653 $aCONTROL AMAMANTAMIENTO 653 $aTABLILLA NASAL 700 1 $aLOPEZ, J.A. 700 1 $aVIANA, S. 700 1 $aJIMENEZ DE ARECHAGA, C. 700 1 $aVELAZCO, J. 700 1 $aPEREYRA, F. 700 1 $aLOPEZ, C. 700 1 $aQUINTANS, G. 773 $tIn: BERRETTA, E.; MONTOSSI, F.; BRITO, G. (Ed.). Alternativas tecnológicas para los sistemas ganaderos del basalto. Montevideo, UY: INIA, 2014.
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